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DSEN Abstract Comparative effectiveness of influenza vaccines in elderly persons Influenza-related complications can lead to hospitalizations and death in seniors Influenza vaccine immunogenicity (antibody response) is lower in seniors vs. those younger Determining the most…

DSEN Abstract Cough and Cold Products Containing Opioids: Prescribing and Patient Utilization Patterns in the Pediatric Population A Health Canada signal assessment led to advisement that children should not use these products to avoid opioid-related risks Knowing prescription…

DSEN Abstract Safety and effectiveness of influenza vaccine during pregnancy This research was funded by the Drug Safety and Effectiveness Network (DSEN) and conducted by the following investigators: Anick Bérard, Vanina Tchuente, Sasha Bernatsky, William Fraser, Caroline Quach.…

DSEN Abstract Drugs for the Treatment and Prevention of Osteoporosis in Post-menopausal Women: A Systematic Review and Network Meta-analysis Summary We conducted a comprehensive systematic review and network meta-analysis to summarize the comparative benefits and harms of oral…

DSEN Abstract SGLT2 Inhibitors and the Risk of Diabetic Ketoacidosis: A study conducted by the Canadian Network for Observational Drug Effect Studies (CNODES) Summary SGLT2 inhibitor use was associated with an increased risk of DKA compared to DPP-4 inhibitors among patients with…

DSEN Abstract Hydrochlorothiazide and the Risk of Skin Cancer Studies conducted by the Canadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) and the Canadian Network for Observational Drug Effect Studies (CNODES) What is the…

DSEN Abstract Active Surveillance & Canadian multi-province Cohorts of Pregnant Women and Children The CAMCCO infrastructure leads to fast-track, valid and reproducible real-world evidence for decision making, and clinical practice guidelines, including identifying serious events…

DSEN Abstract SGLT2 Inhibitors and the Risk of Major Adverse Cardiovascular Events A study conducted by the Canadian Network for Observational Drug Effect Studies (CNODES) SGLT2 inhibitor use was associated with a decreased risk of serious cardiovascular events compared with the…

DSEN Abstract SGLT2 Inhibitors and the Risk of Severe Urinary Tract Infection A study conducted by the Canadian Network for Observational Drug Effect Studies (CNODES) SGLT2 inhibitor use was not associated with an increased risk of severe UTI compared to use of DPP-4 inhibitors…

DSEN Abstract SGLT2 Inhibitors and the Risk of Below-Knee Amputation A study conducted by the Canadian Network for Observational Drug Effect Studies (CNODES) What is the issue? Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of drugs used in the second- or…