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DSEN Abstract 5-HT3 Antagonists (Antiemetics) & Cardiac Safety Authors: SEARCH & PREVENT Team of the CIHR Drug Safety and Effectiveness Network (DSEN) Ondansetron is a highly effective antiemetic for the treatment of nausea and vomiting. However, this medication has also been…

DSEN Abstract No evidence identified interventions that decrease the risk of adverse cardiac events for patients receiving chemotherapy and serotonin 5-hydroxytryptamine 3 receptor (5-HT3) antagonists This research was funded by the Drug Safety and Effectiveness Network (DSEN)…

DSEN Abstract Evaluating Additive Treatment Effects in Network Meta-Analysis This research was funded by the Drug Safety and Effectiveness Network (DSEN) and conducted by the following investigators: Edward Mills, Kristian Thorlund and John Ioannidis. The statements made herein…

DSEN Abstract Efficacy and Safety of Cognitive Enhancers for Mild Cognitive Impairment – A Systematic Review and Meta-analysis This research was funded by the Drug Safety and Effectiveness Network (DSEN) and conducted by the following investigators: Tricco AC, Soobiah C, Berliner…

DSEN Abstract Hair cortisol as a novel biomarker of HPA suppression by inhaled corticosteroids (ICS) in children & pregnant patients with asthma This research was funded by the Drug Safety and Effectiveness Network (DSEN) and conducted by the following investigators: Bruce…

DSEN Abstract Implementation of Pharmacogenomics to Identify Patients at Risk of Statin-Induced Myopathy This research was funded by the Drug Safety and Effectiveness Network (DSEN) and conducted by the following investigators: Richard Kim, Rommel Tirona, Ute Schwarz, Marianne…

DSEN Abstract Comparative effectiveness of pharmacological treatments for rheumatoid arthritis This research was funded by the Drug Safety and Effectiveness Network (DSEN) and conducted by the following investigators: Cristiano S Moura, Jessica Widdifield, Sasha Bernatsky, Michal…

DSEN Abstract High potency statins and rates of admission for acute kidney injury This research was funded by the Drug Safety and Effectiveness Network (DSEN) and conducted by the following investigators: Colin R. Dormuth, Brenda R. Hemmelgarn, J. Michael Paterson, Matthew T.…

DSEN Abstract Identification of Pharmacogenomic Markers of Anthracycline-Induced Cardiotoxicity in Children This research was funded by the Drug Safety and Effectiveness Network (DSEN) and conducted by the following investigators: Bruce Carleton, Colin Ross, Richard Kim and the…

Fall 2020: DSEN Researchers advancing knowledge on COVID-19 DSEN Researchers Advancing Knowledge on COVID-19 DSEN funded teams are involved in the pan-Canadian and global response to the COVID-19 crisis. This edition of the DSEN newsletter focuses on the various ways DSEN…