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DSEN Abstract Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention: A Review of the Clinical Impact of Treatment Duration - An Umbrella Review Summary Nineteen systematic reviews of RCTs were included in this systematic umbrella review. Earlier RCTs primarily…

DSEN Abstract Direct oral anticoagulants for the prevention of venous thromboembolic events in the hospital setting Summary LMWH is more effective than UFH in preventing VTE among hospitalized medical patients, without added bleeding risk. In surgical patients, LMWH may raise…

DSEN Abstract Drugs for the Management of Rheumatoid Arthritis: A Systematic Review with Network Meta-analysis Summary One hundred and one studies were included in this systematic review. Limited information was available for biologic inadequate responders. Key messages For…

DSEN Abstract Efficacy of modified released methylphenidate linked to pharmacokinetic profile: A Rapid Systematic Review This systematic review includes nineteen publications. Extremely limited evidence was located to support the research questions. More research is required to…

DSEN Abstract Impact of using concomitant conventional DMARDs on adherence to biologic DMARD treatment in Rheumatoid Arthritis: Multi-Centre, population-based cohort study (Q14-01) A study conducted by the Canadian Network for Observational Drug Effect Studies (CNODES) There was…

DSEN Abstract Direct oral anticoagulants in venous thromboembolism A study conducted by the Canadian Network for Observational Drug Effect Studies (CNODES) Compared to warfarin, treatment of newly-diagnosed VTE with a DOAC was not associated with an increased risk of major…

DSEN Abstract Hepatitis C Treatments: Contribution of Patient Genetics in Sofosbuvir Treatment Failure Despite low rates of sofosbuvir failure in the pivotal clinical trials (2 - 4%), this real-world trial shows a higher failure rate of 9.5%. This study also found that patients…

DSEN Abstract Direct Oral Anticoagulants for the Acute and Extended Treatment of Venous Thromboembolic Events: A Systematic Review and Network Meta-Analysis This research was funded by the Drug Safety and Effectiveness Network (DSEN) and conducted by the following investigators:…

DSEN Abstract Active surveillance and real world evidence in the evaluation of treaments in patients with chronic hepatitis C At the time of our original grant submission, only three drug regimens were available for the treatment of the hepatitis C virus (HCV), none of which are…

DSEN Abstract Hepatitis C Virus Treatment: Contribution of Patient Genetics in Ribavirin-induced Anemia In the treatment of chronic hepatitis C, ribavirin is often incorporated to improve treatment effectiveness. However, 1 in 3 treated patients develop severe anemia. This study…