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DSEN Abstract Assessing the potential for additive toxicity arising from the combined use of immune checkpoint inhibitors and of tyrosine kinase inhibitors Summary This rapid systematic review examined the potential additive toxicity associated with combined use of immune check…

DSEN Abstract Safety and Immunogenicity of COVID-19 Vaccines in Pediatric Populations with Systemic Immune-Mediated Diseases Canada’s National Advisory Committee on Immunization (NACI) needs evidence on the safety and effectiveness of COVID-19 vaccines in adolescents and children…

DSEN Abstract Hydromorphone controlled release drug injection and hepatitis C virus (HCV), and human immunodeficiency virus (HIV) and infectious endocarditis (IE) infection Injecting oral hydromorphone can lead to serious infections. We observed a higher incidence of HCV…

DSEN Abstract Validation of COVID-19 Diagnoses in Administrative Health Data A study conducted by the Canadian Network for Observational Drug Effect Studies (CNODES). This study provides new information regarding the validity of COVID-19 diagnoses captured in Canadian inpatient…

DSEN Abstract Controlled-release hydromorphone and risk of infection in adults: A Systematic Review The systematic review aimed to examine the risk of infection in PWID exposed to controlled release hydromorphone. Through a thorough search of Embase, Medline and EMB Reviews, we…

DSEN Abstract COVID-19 Infection and Medicines in Pregnancy Understanding the consequences of COVID-19 infection and related treatments on maternal and neonatal health can help support future studies and clinical practice guidelines We aimed to compare medication use in treating…

DSEN Abstract Reliability of COVID-19 case definitions in administrative and clinical databases In 2020, WHO created two new ICD-10 codes related to SARS-CoV2 infection We tested the reliability of these codes compared to PCR testing across 8 provinces in three data sources Using…

DSEN Abstract Active Surveillance for safety and effectiveness of health products for COVID-19: A scoping review Summary This scoping review aimed to examine the evolution of AS systems throughout the COVID-19 pandemic by considering early- (2020) and later-stage (2021 or later)…

DSEN Abstract Risk of arterial and venous thromboembolism events among patients with COVID-19: A multi-national collaboration of regulatory agencies from Canada, Europe, and US A study conducted by the Canadian Network for Observational Drug Effect Studies (CNODES) The risk of…

DSEN Abstract Systemic Corticosteroid Treatment of COVID-19 Outpatients in Canada A study conducted by the Canadian Network for Observational Drug Effect Studies (CNODES) This population-based study of COVID-19 outpatients in three Canadian provinces, demonstrated that use of…